021-51111890
购物车（）
sales@molnova.cn
GSK2807 Trifluoroacetate
CAS No. 2245255-66-5
GSK2807 Trifluoroacetate ( —— )
产品货号. M22934 CAS No. 2245255-66-5
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1596 | 有现货 |
|
| 10MG | ￥2341 | 有现货 |
|
| 25MG | ￥3953 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称GSK2807 Trifluoroacetate
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3.
-
产品描述GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively).
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体SMYD3
-
研究领域——
-
适应症——
化学信息
-
CAS Number2245255-66-5
-
分子量566.53
-
分子式C21H33F3N8O7
-
纯度>98% (HPLC)
-
溶解度H2O:50 mg/mL (88.26 mM)
-
SMILESNC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC[C@H](N)C(O)=O)CCCN(C)C)O3)C=N2)=NC=N1.OC(C(F)(F)F)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Van Aller GS, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781.
产品手册
关联产品
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
-
Theaflavanoside II
The peels of Citrus maxima.
-
Physapruin A
Physapruin A is a natural product from Physalis pruinosa.
